Publications

  1. DIGGER 2.0: digging into the functional impact of differential splicing on human and mouse disorders
    Elias Albrecht, Konstantin Pelz, Alexander Gress, Hieu Nguyen Trung, Olga V Kalinina, Tim Kacprowski, Jan Baumbach, Markus List, Olga Tsoy
    https://doi.org/10.1093/nar/gkaf384
  2. Distinct inflammatory imprint in non-cirrhotic and cirrhotic patients before and after direct-acting antiviral therapy
    Moana Witte, Carlos Oltmanns, Jan Tauwaldt, Hagen Schmaus, Jasmin Mischke, Gordon Grabert, Mara Bretthauer, Lennart M. Roesner, Thomas Werfel, Katja Deterding, Benjamin Maasoumy, Heiner Wedemeyer, Tim Kacprowski, Anke R. M. Kraft, Markus Cornberg
    https://doi.org/10.3350/cmh.2025.0292
  3. Domain Specific Transfer Learning and Classifier Chains in Alzheimer’s Disease Detection using 3D Convolutional Neural Networks
    Lisa-Marie Bente, Luca Himstedt, Tim Kacprowski
    https://doi.org/10.1016/j.imu.2025.101711
  4. Integrative multi-omics analysis of growth plate regulation underlying body size in miniature pigs (Preprint)
    Nadia Khaveh, Jan Berghöfer, Ralph Brehm, René Buschow, Karsten Cirksena, Cord Drögemüller, Abeera Fatima, Gordon Grabert, Gisa Gerold, Alexander Grahofer, Ralf Herwig, Klaus Jung, Tim Kacprowski, Bai-Wei Lo, Roya Shiasi Sardoabi, Martin Vingron, Stefan Mundlos, Julia Metzger
    https://doi.org/10.21203/rs.3.rs-7865536/v1
  5. Large language models for surgical informed consent: An ethical perspective on simulated empathy.
    Pranab Rudra,  Wolf-Tilo Balke,  Tim Kacprowski, Frank Ursin, Sabine Salloch
    https://doi.org/10.1136/jme-2024-110652
  6. The haplotype-resolved assembly of COL40 a cassava (Manihot esculenta) line with broad-spectrum resistance against viruses causing Cassava brown streak disease unveils a region of highly repeated elements on chromosome 12
    Corinna Thoben    , Boas Pucker, Stephan Winter, Bethany Fallon Econopouly, Samar Sheat
    https://doi.org/10.1093/g3journal/jkaf083
  7. Zusammenwirken von natürlicher und künstlicher Intelligenz: Beurteilen – Messen – Bewerten
     Otto Richter, Uwe Drewitz, Reinhold Haux, Stefan Heuser, Tim Kacprowski, Jochen Steil
    https://doi.org/10.1007/978-3-658-45845-4.
  1.  Inference of differential gene regulatory networks using boosted differential trees
    Gihanna Galindez, Markus List, Jan Baumbach, Uwe Völker, Ulrike Mäder, David B. Blumenthal, Tim Kacprowski
    https://doi.org/10.1093/bioadv/vbae034
  2. MeTEor: an R Shiny app for exploring longitudinal metabolomics data
    Gordon Grabert, Daniel Dehncke, Tushar More, Markus List, Anke R. M. Kraft, Markus Cornberg, Karsten Hiller, Tim Kacprowski
    https://doi.org/10.1093/bioadv/vbae178
  3. Network medicine-based epistasis detection in complex diseases: ready for quantum computing
    Markus Hoffmann, Julian M. Poschenrieder, Massimiliano Incudini, Sylvie Baier, Amelie Fritz, Andreas Maier, Michael Hartung, Christian Hoffmann, Nico Trummer, Klaudia Adamowicz, Mario Picciani, Evelyn Scheibling, Maximilian V. Harl, Ingmar Lesch, Hunor Frey, Simon Kayser, Paul Wissenberg, Leon Schwartz, Leon Hafner, Aakriti Acharya, Lena Hackl, Gordon Grabert, Sung-Gwon Lee, Gyuhyeok Cho, Matthew E. Cloward, Jakub Jankowski, Hye K. Lee, Olga Tsoy, Nina Wenke, Anders G. Pedersen, Klaus Bønnelykke, Antonio Mandarino, Federico Melograna, Laura Schulz, Héctor Climente-González, Mathias Wilhelm, Luigi Iapichino, Lars Wienbrandt, David Ellinghaus, Kristel Van Steen, Michele Grossi, Priscilla A. Furth, Lothar Hennighausen, Alessandra Di Pierro, Jan Baumbach, Tim Kacprowski, Markus List, David B. Blumenthal
    https://doi.org/10.1093/nar/gkae697
  4. On the limits of 16S rRNA gene-based metagenome prediction
    and functional profiling
    Monica S. Matchado, Malte Rühlemann, Sandra Reitmeier, Tim Kacprowski, Fabian Frost, Dirk Haller, Jan Baumbach, Markus List
    https://doi.org/10.1099/mgen.0.001203
  5. Real-time ECG-monitoring in virtual reality
    Willi Schüler, Lisa-Marie Bente, Thomas M. Deserno, Tim Kacprowski
    https://doi.org/10.1117/12.3006472
  6. VISPER-Visualization System for Interactions between Proteins and Drugs for Exploratory Research
    Daniel Dehncke, Vinzenz Fiebach, Lennart Kinzel, Knut Baumann, Tim Kacprowski
    https://doi.org/10.2312/vcbm.20241190
  1. Alternative splicing analysis benchmark with DICAST
    Amit Fenn, Olga Tsoy, Tim Faro, Fanny L. M. Rößler, Alexander Dietrich, Johannes Kersting, Zakaria Louadi, Chit Tong Lio, Uwe Völker, Jan Baumbach, Tim Kacprowski, Markus List
    https://doi.org/10.1093/nargab/lqad044
  2. Alternative splicing impacts microRNA regulation within coding regions
    Lena M. Hackl, Amit Fenn, Zakaria Louadi, Jan Baumbach, Tim Kacprowski, Markus List, Olga Tsoy
    https://doi.org/10.1093/nargab/lqad081
  3. ATF6 activation alters colonic lipid metabolism causing tumor-associated microbial adaptation 
    Olivia I. Coleman, Adam Sorbie, Alessandra Riva, Miriam von Stern, Stephanie Kuhls, Denise M. Selegato, Nikolai Köhler, Jakob Wirbel, Tim Kacprowski, Andreas Dunkel, Josh K. Pauling, Johannes Plagge, Diego Mediel-Cuadra, Sophia Wagner, Ines Chadly, Sandra Bierwith, Tingying Peng, Thomas Metzler, Clemens Schafmayer, Sebastian Hinz, Christian Röder, Christoph Röcken, Michael Zimmermann, Philip Rosenstiel, Katja Steiger, Moritz Jesinghaus, Gerhard Liebisch, Josef Ecker, Christina Schmidt, Georg Zeller, Klaus-Peter Janssen, Dirk Haller
    https://doi.org/10.1101/2023.11.03.565267.
  4. Fake paper identification in the pool of withdrawn and rejected manuscripts submitted to Naunyn–Schmiedeberg’s Archives of Pharmacology
    Jonathan Wittau,  Serkan Celik, Tim Kacprowski, Thomas M. Deserno, Roland Seifert
    https://doi.org/10.1007/s00210-023-02741-w
  5.  Independent Tissue-Based Biomarkers in Endometrioid Endometrial Cancer: Tumor Budding in Microsatellite Instability and WHO Grading in Copy-Number-Low Patients
    Fabian Stögbauer, Barbara Geß, Christine Brambs, Manuela Lautizi, Tim Kacprowski, Iordanis Ourailidis, Holger Bronger, Marion Kiechle, Aurelia Noske, Gisela Keller, Moritz Jesinghaus, Christopher Poremba, Wilko Weichert, Melanie Boxberg
    https://doi.org/10.3390/cancers15153832
  6. Lacking mechanistic disease definitions and corresponding association data hamper progress in network medicine and beyond
    Sepideh Sadegh, James Skelton, Elisa Anastasi, Andreas Maier, Klaudia Adamowicz, Anna Möller, Nils M. Kriege, Jaanika Kronberg, Toomas Haller, Tim Kacprowski, Anil Wipat, Jan Baumbach, David B. Blumenthal 
    https://doi.org/10.1038/s41467-023-37349-4
  7. Network-based approaches for modeling disease regulation and
    progression
    Gihanna Galindez    , Sepideh Sadegh, Jan Baumbach, Tim Kacprowski, Markus List
    https://doi.org/10.1016/j.csbj.2022.12.022
  8. New Enhancing MRI Lesions Associate with IL-17, Neutrophil Degranulation and Integrin Microparticles: Multi-Omics Combined with Frequent MRI in Multiple Sclerosis
    Zsolt Illes, Malene Møller Jørgensen, Rikke Bæk, Lisa-Marie Bente, Jørgen T. Lauridsen, Kirsten H. Hyrlov, Christopher Aboo, Jan Baumbach, Tim Kacprowski, Francois Cotton, Charles R. G. Guttmann, Allan Stensballe
    https://doi.org/10.3390/biomedicines11123170
  9. Should Artificial Intelligence be used to support clinical ethical decision-making? A systematic review of reasons
    Lasse Benzinger, Frank Ursin, Wolf‑Tilo Balke, Tim Kacprowski, Sabine Salloch
    https://doi.org/10.1186/s12910-023-00929-6
  10. Systematic analysis of alternative splicing in time course data using Spycone
    Chit T. Lio, Gordon Grabert, Zakaria Louadi, Amit Fenn, Jan Baumbach, Tim Kacprowski, Markus List, Olga Tsoy
    https://doi.org/10.1093/bioinformatics/btac846
  11. The FeatureCloud Platform for Federated Learning in Biomedicine: Unified Approach
    Julian Matschinske,  Julian Späth,  Mohammad Bakhtiari, Niklas Probul, Mohammad M. K. Majdabadi, Reza Nasirigerdeh,  Reihaneh Torkzadehmahani,  Anne Hartebrodt, Balazs-Attila Orban, Sándor-József Fejér,  Olga Zolotareva,  Supratim Das,  Linda Baumbach,  Josch K. Pauling, Olivera Tomašević, Béla Bihari, Marcus Bloice, Nina C. Donner,  Walid Fdhila,  Tobias Frisch,  Anne-Christin Hauschild, Dominik Heider,  Andreas Holzinger,  Walter Hötzendorfer,  Jan Hospes,  Tim Kacprowski,  Markus Kastelitz, Markus List, Rudolf Mayer, Mónika Moga,  Heimo Müller,  Anastasia Pustozerova,  Richard Röttger, Christina C. Saak,  Anna Saranti,  Harald H. H. W. Schmidt, Christof Tschohl, Nina K. Wenke,  Jan Baumbach
    https://doi.org/10.2196/42621
  1. A zlog-based algorithm and tool for plausibility checks of reference intervals
    Sandra Klawitter, Georg Hoffmann, Stefan Holdenrieder, Tim Kacprowski, Frank Klawonn 

    https://doi.org/10.1515/cclm-2022-0688

  2. Alternative splicing analysis benchmark with DICAST
    Amit Fenn, Olga Tsoy, Tim Faro, Fanny Rössler, Alexander Dietrich, Johannes Kersting, Zakaria Louadi, Chit Tong Lio, Uwe Völker, Jan Baumbach, Tim Kacprowski, Markus List

    https://doi.org/10.1101/2022.01.05.475067

  3. Forecasting admissions in psychiatric hospitals before and during Covid-19: a retrospective study with routine data
    Jan Wolff, Ansgar Klimke, Michael Marschollek, Tim Kacprowski

    https://doi.org/10.1038/s41598-022-20190-y

  4. Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate
    Aniket Mishra, Cécile Duplaà, Dina Vojinovic, Hideaki Suzuki, Muralidharan Sargurupremraj, Nuno R. Zilhão, Shuo Li, Traci M. Bartz, Xueqiu Jian, Wei Zhao, Edith Hofer, Katharina Wittfeld, Sarah E. Harris, Sandra van der Auwera-Palitschka, Michelle Luciano, Joshua C. Bis, Hieab H. H. Adams, Claudia L. Satizabal, Rebecca F. Gottesman, Piyush G. Gampawar, Robin Bülow, Stefan Weiss, Miao Yu, Mark E. Bastin, Oscar L. Lopez, Meike W. Vernooij, Alexa S. Beiser, Uwe Völker, Tim Kacprowski, Aicha Soumare, Jennifer A. Smith, David S. Knopman, Zoe Morris, Yicheng Zhu, Jerome I. Rotter, Carole Dufouil, Maria Valdés Hernández, Susana Muñoz Maniega, Mark Lathrop, Erik Boerwinkle, Reinhold Schmidt, Masafumi Ihara, Bernard Mazoyer, Qiong Yang, Anne Joutel, Elizabeth Tournier-Lasserve, Lenore J. Launer, Ian J. Deary, Thomas H. Mosley, Philippe Amouyel, Charles S. DeCarli, Bruce M. Psaty, Christophe Tzourio, Sharon L. R. Kardia, Hans J. Grabe, Alexander Teumer, Cornelia M. van Duijn, Helena Schmidt, Joanna M. Wardlaw, Mohammad A. Ikram, Myriam Fornage, Vilmundur Gudnason, Sudha Seshadri, Paul M. Matthews, William T. Longstreth, Thierry Couffinhal, Stephanie Debette

    https://doi.org/10.1093/brain/awab432

  5. Hypothesis of a potential BrainBiota and its relation to CNS autoimmune inflammation
    Maria L. Elkjaer, Lukas Simon, Tobias Frisch, Lisa-Marie Bente, Tim Kacprowski, Mads Thomassen, Richard Reynolds, Jan Baumbach, Richard Röttger, Zsolt Illes
    https://doi.org/10.3389/fimmu.2022.1043579 
  6. P057 Mucosal microbiota adapts to ATF6-induced alterations in host lipid metabolism with prognostic value in colorectal cancer
    Sandra Bierwirth, Adam Sorbie, Olivia I. Coleman, Elena M. Reuß, Philipp Weber, Nikolai Köhler, Tim Kacprowski, Andreas Dunkel, Josch K. Pauling, Josef Ecker, Jan Baumbach, Philip Rosenstiel, Katja Steiger, Jakob Wirbel, Georg Zeller, Klaus-Peter Janssen, Dirk Haller
    https://doi.org/10.1093/ecco-jcc/jjab232.186
  7. Privacy-Preserving Artificial Intelligence Techniques in Biomedicine
    Reihaneh Torkzadehmahani, Reza Nasirigerdeh, David B. Blumenthal, Tim Kacprowski, Markus List, Julian Matschinske, Julian Spaeth, Nina Kerstin Wenke, Jan Baumbach
    https://doi.org/10.1055/s-0041-1740630
  8. Robust disease module mining via enumeration of diverse prize-collecting Steiner trees
    Judith Bernett, Dominik Krupke, Sepideh Sadegh, Jan Baumbach, Sándor P. Fekete, Tim Kacprowski, Markus List, David B. Blumenthal
    https://doi.org/10.1093/bioinformatics/btab876
  9. Small RNA Sequencing in the Tg4–42 Mouse Model Suggests the Involvement of snoRNAs in the Etiology of Alzheimer’s Disease
    Chit T. Long, Tim Kacprowski, Maik Klaedtke, Lars R. Jensen, Yvonne Bouter, Thomas A. Bayer, Andreas W. Kuss
    https://doi.org/10.3233/JAD-220110
  10. sPLINK: a hybrid federated tool as a robust alternative to meta-analysis in genome-wide association studies
    Reza Nasirigerdeh, Reihaneh Torkzadehmahani, Julian Matschinske, Tobias Frisch, Markus List, Julian Späth, Stefan Weiss, Uwe Völker, Esa Pitkänen, Dominik Heider, Nina K. Wenke, Georgios Kaissis, Daniel Rueckert, Tim Kacprowski, Jan Baumbach
    https://doi.org/10.1186/s13059-021-02562-1
  11. Systematic analysis of alternative splicing in time course data using Spycone
    Chit Tong Lio, Zakaria Louadi, Amit Fenn, Jan Baumbach, Tim Kacprowski, Markus List, Olga Tsoy

    https://doi.org/10.1101/2022.04.28.489857

  12. The Limits of Molecular Signatures for Pancreatic Ductal Adenocarcinoma Subtyping
    Manuela Lautizi, Jan Baumbach, Wilko Weichert, Katja Steiger, Markus List, Nicole Pfarr, Tim Kacprowski

    https://doi.org/10.1101/2022.05.16.491983

  13. Tumour cell budding and spread through air spaces in squamous cell carcinoma of the lung – Determination and validation of optimal prognostic cut-offs
    Fabian Stögbauer, Manuela Lautizi, Mark Kriegsmann, Hauke Winter, Thomas Muley, Katharina Kriegsmann, Moritz Jesinghaus, Jan Baumbach, Peter Schüffler, Wilko Weichert, Tim Kacprowski, Melanie Boxberg

    https://doi.org/10.1016/j.lungcan.2022.04.012

  1. A framework for modeling epistatic interaction
    David B. Blumenthal, Jan Baumbach, Markus Hoffmann, Tim Kacprowski, Markus List
    https://doi.org/10.1093/bioinformatics/btaa990
  2. ASimulatoR: splice-aware RNA-Seq data simulation
    Quirin Manz, Olga Tsoy, Amit Fenn, Jan Baumbach, Uwe Völker, Markus List, Tim Kacprowski
    https://doi.org/10.1093/bioinformatics/btab142
  3. Carrying asymptomatic gallstones is not associated with changes in intestinal microbiota composition and diversity but cholecystectomy with significant dysbiosis
    Fabian Frost, Tim Kacprowski, Malte Rühlemann, Stefan Weiss, Corinna Bang, Andre Franke, Maik Pietzner, Ali A. Aghdassi, Matthias Sendler, Uwe Völker,
    Henry Völzke, Julia Mayerle, Frank U. Weiss, Georg Homuth, Markus M. Lerch
    https://doi.org/10.1038/s41598-021-86247-6
  4. CSF proteome in multiple sclerosis subtypes related to brain lesion transcriptomes
    Maria L. Elkjaer, Arkadiusz Nawrocki, Tim Kacprowski, Pernille Lassen, Anja Hviid Simonsen, Romain Marignier, Tobias Sejbaek, Helle H. Nielsen,
    Lene Wermuth, Alyaa Yakut Rashid, Peter Høgh, Finn Sellebjerg, Richard Reynolds, Jan Baumbach, Martin R. Larsen, Zsolt Illes
    https://doi.org/10.1038/s41598-021-83591-5
  5. Enabling single-cell trajectory network enrichment
    Alexander G. B. Grønning, Mhaned Oubounyt, Kristiyan Kanev, Jesper Lund, Tim Kacprowski, Dietmar Zehn, Richard Röttger, Jan Baumbach
    https://doi.org/10.1038/s43588-021-00025-y
  6. Functional enrichment of alternative splicing events with NEASE reveals insights into tissue identity and diseases
    Zakaria Louadi, Maria L. Elkjaer, Melissa Klug, Chit Tong Lio, Amit Fenn, Zsolt Illes, Dario Bongiovanni, Jan Baumbach, Tim Kacprowski, Markus List, Olga Tsoy
    https://doi.org/10.1186/s13059-021-02538-1
  7. Genome‑wide analysis of mitochondrial DNA copy number reveals loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation
    Ryan J. Longchamps,  Stephanie Y. Yang,  Christina A. Castellani, Wen Shi, John Lane, Megan L. Grove,  Tracy M. Bartz, Chloé Sarnowski, Chunyu Liu, Kimberly Burrows, Anne L. Guyatt, Tom R. Gaunt, Tim Kacprowski, Jing Yang, Philip L. De Jager, Lz Yu, Aviv Bergman, Rui Xia, Myriam Fornage, Mary F. Feitosa, Mary K. Wojczynski, Aldi T. Kraja, Michael A. Province, Naseer Amin, Fanny Rivadeneira, Henning Tiemeier, André G. Uitterlinden, Linda Broer, Joyce B. J. Van Meurs, Cornelia M. Van Duijn, Laura M. Raffield,  Leslie Lange, Stephen S. Rich, Rozenn N. Lemaitre, Mark O. Goodarzi, Colleen M. Sitlani, Angel C. Y. Mak, David A. Bennett, Santiago Rodriguez, J. M. Murabito, Kathryn L. Lunetta, N. Sotoodehnia, Gil Atzmon, Kenny Ye, Nir Barzilai, Jennifer A. Brody,  Bruce M. Psaty, Kent D. Taylor, Jerome I. Rotter, Eric Boerwinkle, Nathan Pankratz, Dan E. Arking
    https://doi.org/10.1007/s00439-021-02394-w
  8. Lessons from the COVID-19 pandemic for advancing computational drug repurposing strategies
    Gihanna Galindez, Julian Matschinske, Tim Daniel Rose , Sepideh Sadegh, Marisol Salgado-Albarrán, Julian Späth, Jan Baumbach, Josch Konstantin Pauling
    https://doi.org/10.1038/s43588-020-00007-6
  9. Long-term instability of the intestinal microbiome is associated with metabolic liver disease, low microbiota diversity, diabetes mellitus and impaired exocrine pancreatic function
    Fabian Frost, Tim Kacprowski, Malte Rühlemann, Maik Pietzner, Corinna Bang, Andre Franke, Matthias Nauck, Uwe Völker, Henry Völzke, Marcus Dörr, Jan Baumbach, Matthias Sendler, Christian Schulz, Julia Mayerle, Frank U. Weiss, Georg Homuth, Markus M. Lerch
    https://doi.org/10.1136/gutjnl-2020-322753
  10. MultiPep: a hierarchical deep learning approach for multi-label classification of peptide bioactivities
    Alexander G. B. Grønning, Tim Kacprowski, Camilla Schéele
    https://doi.org/10.1093/biomethods/bpab021
  11. Network analysis methods for studying microbial communities: A mini review
    Monica Steffi Matchado, Michael Lauber, Sandra Reitmeier, Tim Kacprowski, Jan Baumbach, Dirk Haller, Markus List
    https://doi.org/10.1016/j.csbj.2021.05.001
  12. Network medicine for disease module identification and drug repurposing with the NeDRex platform
    Sepideh Sadegh, James Skelton, Elisa Anastas, Judith Bernett,  David B. Blumenthal, Gihanna Galindez, Marisol Salgado-Albarrán, Olga Lazareva, Keith Flanagan, Simon Cockell, Cristian Nogales, Ana I. Casas, Harald H. H. W. Schmidt, Jan Baumbach ,  Anil Wipat, Tim Kacprowski
    https://doi.org/10.1038/s41467-021-27138-2
  13. The AIMe registry for artificial intelligence in biomedical research
    Julian Matschinske, Nicolas Alcaraz, Arriel Benis, Martin Golebiewski, Dominik G. Grimm, Lukas Heumos, Tim Kacprowski, Olga Lazareva, Markus List, Zakaria Louadi, Josch K. Pauling, Nico Pfeifer, Richard Röttger, Veit Schwämmle, Gregor Sturm, Alberto Traverso, Kristel Van Steen, Martiela Vaz de Freitas, Gerda Cristal Villalba Silva, Leonard Wee, Nina K. Wenke, Massimiliano Zanin, Olga Zolotareva, Jan Baumbach and David B. Blumenthal
    https://doi.org/10.1038/s41592-021-01241-0
  14. Transcriptome analysis of growth variation in early juvenile stage sandfish Holothuria scabra
    June Feliciano F. Ordoñez, Gihanna Gaye S.T. Galindez, Karina Therese Gulay, Rachel Ravago-Gotanco
    https://doi.org/10.1016/j.cbd.2021.100904
  15. Whole-body R2∗ mapping to quantify tissue iron in iron storage organs: reference values and a genotype
    Mary L. Kromrey, Anne Röhnert, Sophia Blum, Robert Winzer, Ralf T. Hoffman, Henry Völzke, Tim Kacprowski, Jens-Peter Kühn
    https://doi.org/10.1016/j.crad.2021.05.016
  1. Association of proteome and metabolome signatures with severity in patients with community-acquired pneumonia
    Manuela Gesell Salazar, Sophie Neugebauer, Tim Kacprowski, Stephan Michalik, Peter Ahnert, Petra Creutz, Maciej Rosolowski, Markus Löffler, Michael Bauer, Norbert Suttorp, Michael Kiehntopf, Uwe Völker

    https://doi.org/10.1016/j.jprot.2019.103627

  2. Comparative single-cell trajectory network enrichment identifies pseudo-temporal systems biology patterns in hematopoiesis and CD8 T-cell development
    Alexander G. B. Grønning, Mhaned Oubounyt, Kristiyan Kanev, Jesper Lund, Tim Kacprowski, Dietmar Zehn, Richard Röttger, Jan Baumbach

    https://doi.org/10.1101/2020.04.02.021295

  3. EpiGEN: an epistasis simulation pipeline
    David B. Blumenthal, Lorenzo Viola, Markus List, Jan Baumbach, Paolo Tieri, Tim Kacprowski

    https://doi.org/10.1093/bioinformatics/btaa245

  4. Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing
    Sepideh Sadegh1, Julian Matschinske, David B. Blumenthal, Gihanna Galindez, Tim Kacprowski, Markus List, Reza Nasirigerdeh, Mhaned Oubounyt, Andreas Pichlmair, Tim Daniel Rose, Marisol Salgado-Albarrán, Julian Späth, Alexey Stukalov, Nina K. Wenke, Kevin Yuan, Josch K. Pauling, Jan Baumbach

    https://doi.org/10.1038/s41467-020-17189-2

  5. Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity
    Hanieh Yaghootkar, Yiying Zhang, Cassandra N. Spracklen, Tugce Karaderi, Lam Opal Huang, Jonathan Bradfield, Claudia Schurmann, Rebecca S. Fine, Michael H. Preuss, Zoltan Kutalik, Laura B.L. Wittemans, Yingchang Lu, Sophia Metz, Sara M. Willems, Ruifang Li-Gao, Niels Grarup, Shuai Wang, Sophie Molnos, América A. Sandoval-Zárate, Mike A. Nalls, Leslie A. Lange, Jeffrey Haesser, Xiuqing Guo, Leo-Pekka Lyytikäinen, Mary F. Feitosa, Colleen M. Sitlani, Cristina Venturini, Anubha Mahajan, Tim Kacprowski, Carol A. Wang, Daniel I. Chasman, Najaf Amin, Linda Broer, Neil Robertson, Kristin L. Young, Matthew Allison, Paul L. Auer, Matthias Blüher, Judith B. Borja, Jette Bork-Jensen, Germán D. Carrasquilla, Paraskevi Christofidou, Ayse Demirkan, Claudia A. Doege, Melissa E. Garcia, Mariaelisa Graff, Kaiying Guo, Hakon Hakonarson, Jaeyoung Hong, Yii-Der Ida Chen, Rebecca Jackson, Hermina Jakupović, Pekka Jousilahti, Anne E. Justice, Mika Kähönen, Jorge R. Kizer, Jennifer Kriebel, Charles A. LeDuc, Jin Li, Lars Lind, Jian’an Luan, David A. Mackey, Massimo Mangino, Satu Männistö, Jayne F. Martin Carli, Carolina Medina-Gomez, Dennis O. Mook-Kanamori, Andrew P. Morris, Renée de Mutsert, Matthias Nauck, Ivana Prokic, Craig E. Pennell, Arund D. Pradhan, Bruce M. Psaty, Olli T. Raitakari, Robert A. Scott, Tea Skaaby, Konstantin Strauch, Kent D. Taylor, Alexander Teumer, Andre G. Uitterlinden, Ying Wu, Jie Yao, Mark Walker, Kari E. North, Peter Kovacs, M. Arfan Ikram, Cornelia M. van Duijn, Paul M. Ridker, Stephen Lye, Georg Homuth, Erik Ingelsson, Tim D. Spector, Barbara McKnight, Michael A. Province, Terho Lehtimäki, Linda S. Adair, Jerome I. Rotter, Alexander P. Reiner, James G. Wilson, Tamara B. Harris, Samuli Ripatti, Harald Grallert, James B. Meigs, Veikko Salomaa, Torben Hansen, Ko Willems van Dijk, Nicholas J. Wareham, Struan F.A. Grant, Claudia Langenberg, Timothy M. Frayling, Cecilia M. Lindgren, Karen L. Mohlke, Rudolph L. Leibel, Ruth J.F. Loos, Tuomas O. Kilpeläinen

    https://doi.org/10.2337/db20-0070

  6.  Genetic studies of urinary metabolites illuminate mechanisms of detoxification and excretion in humans
    Pascal Schlosser, Yong Li, Peggy Sekula, Johannes Raffler, Franziska Grundner-Culemann, Maik Pietzner, Yurong Cheng, Matthias Wuttke, Inga Steinbrenner, Ulla T. Schultheiss, Fruzsina Kotsis, Tim Kacprowski, Lukas Forer, Birgit Hausknecht, Arif B. Ekici, Matthias Nauck, Uwe Völker, GCKD Investigators, Gerd Walz, Peter J. Oefner, Florian Kronenberg, Robert P. Mohney, Michael Köttgen, Karsten Suhre, Kai-Uwe Eckardt, Gabi Kastenmüller, Anna Köttgen

    https://doi.org/10.1038/s41588-019-0567-8 

  7. Importance of considering the growth response after partial harvesting and economic risk of discounted net revenues when optimizing uneven-aged forest management
    Katharina Messerer, Tim Kacprowski, Horst Kolo, Jan Baumbach, and Thomas Knoke

    https://doi.org/10.1139/cjfr-2018-0546

  8. Long-term instability of the intestinal microbiome is associated with metabolic liver disease, low microbiota diversity, diabetes mellitus and impaired exocrine pancreatic function
    Fabian Frost, Tim Kacprowski, Malte Rühlemann, Maik Pietzner,
    Corinna Bang, Andre Franke, Matthias Nauck, Uwe Völker, Henry Völzke,
    Marcus Dörr, Jan Baumbach, Matthias Sendler, Christian Schulz,
    Julia Mayerle, Frank U. Weiss, Georg Homuth, Markus M. Lerch

    http://dx.doi.org/10.1136/gutjnl-2020-322753

  9. miRNA Alterations Elicit Pathways Involved in Memory Decline and Synaptic Function in the Hippocampus of Aged Tg4-42 Mice
    Yvonne Bouter, Tim Kacprowski, Fanny Rößler, Lars R. Jensen,
    Andreas W. Kuss, Thomas A. Bayer

    https://doi.org/10.3389/fnins.2020.580524

  10. Multiple Sclerosis Atlas: A Molecular Map of Brain Lesion Stages in Progressive Multiple Sclerosis
    Tobias Frisch, Maria L. Elkjaer, Richard Reynolds, Tanja Maria Michel, Tim Kacprowski, Mark Burton, Torben A. Kruse, Mads Thomassen, Jan Baumbach, Zsolt Illes

    https://doi.org/10.1089/nsm.2020.0006

  11. NOX5-induced uncoupling of endothelial NO synthase is a causal mechanism and theragnostic target of an age-related hypertension endotype
    Mahmoud H. Elbatreek, Sepideh Sadegh, Elisa Anastasi, Emre Guney,
    Cristian Nogales, Tim Kacprowski, Ahmed A. Hassan, Andreas Teubner, Po-Hsun Huang, Chien-Yi Hsu, Paul M. H. Schiffers, Ger M. Janssen, Pamela W.M. Kleikers, Anil Wipat, Jan Baumbach, Jo G. R. De Mey, Harald H. H. W. Schmidt 

    https://doi.org/10.1371/journal.pbio.3000885

  12. PySCNet: A tool for reconstructing and analyzing gene regulatory network from single-cell RNA-Seq data
    Ming Wu, Tim Kacprowski, Dietmar Zehn

    https://doi.org/10.1101/2020.12.18.423482

  13. sPLINK: a hybrid federated tool as a robust alternative to meta-analysis in genome-wide association studies
    Reza Nasirigerdeh, Reihaneh Torkzadehmahani, Julian Matschinske, Tobias Frisch, Markus List, Julian Späth, Stefan Weiss, Uwe Völker, Esa Pitkänen, Dominik Heider, Nina Kerstin Wenke, Georgios Kaissis, Daniel Rueckert, Tim Kacprowski, Jan Baumbach

    https://doi.org/10.1186/s13059-021-02562-1

  14. The Gut Microbiome in Patients With Chronic Pancreatitis Is Characterized by Significant Dysbiosis and Overgrowth by Opportunistic Pathogens
    Fabian Frost, Frank U. Weiss, Matthias Sendler, Tim Kacprowski, Malte Rühlemann, Corinna Bang, Andre Franke, Uwe Völker , Henry Völzke, Georg Lamprecht, Julia Mayerle, Ali A. Aghdassi, Georg Homuth,  Markus M. Lerch 

    https://doi.org/10.14309/ctg.0000000000000232

  15. The Polygenic and Monogenic Basis of Blood Traits and Diseases
    Dragana Vuckovic, Erik L. Bao, Parsa Akbari, Caleb A. Lareau, Abdou
    Mousas, Tao Jiang, Ming-Huei Chen, Laura M. Raffield, Manuel Tardaguila, Jennifer E. Huffman, Scott C. Ritchie, Karyn Megy, Hannes Ponstingl, Christopher J. Penkett, Patrick K. Albers, Emilie M. Wigdor, Saori Sakaue, Arden Moscati, Regina Manansala, Ken Sin Lo, Huijun Qian, Masato Akiyama, Traci M. Bartz, Yoav Ben-Shlomo, Andrew Beswick, Jette Bork- Jensen, Erwin P. Bottinger, Jennifer A. Brody, Frank J.A. Van Rooij, Kumaraswamy N. Chitrala, Peter W.F. Wilson, Hélène Choquet, John Danesh, Emanuele Di Angelantonio, Niki Dimou, Jingzhong Ding, Paul Elliott, Tõnu Esko, Michele K. Evans, Stephan B. Felix, James S. Floyd, Linda Broer, Niels Grarup, Michael H. Guo, Qi Guo, Andreas Greinacher, Jeff Haessler, Torben Hansen, Joanna M.M. Howson, Wei Huang, Eric Jorgenson, Tim Kacprowski, Mika Kähönen, Yoichiro Kamatani, Masahiro Kanai, Savita Karthikeyan, Fotios Koskeridis, Leslie A. Lange, Terho Lehtimäki, Allan Linneberg, Yongmei Liu, Leo-Pekka Lyytikäinen, Ani Manichaikul, Koichi Matsuda, Karen L. Mohlke, Nina Mononen, Yoshinori Murakami, Girish N. Nadkarni, Kjell Nikus, Nathan Pankratz, Oluf Pedersen, Michael Preuss, Bruce M. Psaty, Olli T. Raitakari, Stephen S. Rich, Benjamin A.T. Rodriguez, Jonathan D. Rosen, Jerome I. Rotter, Petra Schubert, Cassandra N. Spracklen, Praveen Surendran, Hua Tang, Jean-Claude Tardif, Mohsen Ghanbari, Uwe Völker, Henry Völzke, Nicholas A. Watkins, Stefan Weiss, Na Cai, Kousik Kundu, Stephen B. Watt, Klaudia Walter, Alan B. Zonderman, Kelly Cho, Yun Li, Ruth J.F. Loos, Julian C. Knight, Michel Georges, Oliver Stegle, Evangelos Evangelou, Yukinori Okada, David J. Roberts, Michael Inouye, Andrew D. Johnson, Paul L. Auer, William J. Astle, Alexander P. Reiner, Adam S. Butterworth, Willem H. Ouwehand, Guillaume Lettre, Vijay G. Sankaran, and Nicole Soranzo.

    https://doi.org/10.1016/j.cell.2020.08.008

  16. Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations
    Ming-Huei Chen, Laura M. Raffield, Abdou Mousas, Saori Sakaue, Jennifer E. Huffman,  Arden Moscati, Bhavi Trivedi, Tao Jiang, Parsa Akbari, Dragana Vuckovic, Erik L. Bao, Xue Zhong, Regina Manansala, Véronique Laplante,  Minhui Chen, Ken Sin Lo, Huijun Qian, Caleb A. Lareau, Mélissa Beaudoin,  Karen A. Hunt, Masato Akiyama, Traci M. Bartz,  Yoav Ben-Shlomo, Andrew Beswick, Jette Bork-Jensen, Erwin P. Bottinger, Jennifer A. Brody, Frank J.A.Van Rooij, Kumaraswamynaidu Chitrala, Kelly Cho, Hélène Choquet, Adolfo Correa, John Danesh, Emanuele Di Angelantonio, Niki Dimou, Jingzhong Ding, Paul Elliott, Tõnu Esko, Michele K. Evans,  James S. Floyd,  Linda Broer, Niels Grarup, Michael H. Guo, Andreas Greinacher, Jeff Haessler, Torben Hansen, Joanna M.M. Howson, Qin Qin Huang, Wei Huang, Eric Jorgenson, Tim Kacprowski, Mika Kähönen, Yoichiro Kamatani, Masahiro Kanai, Savita Karthikeyan, Fotis Koskeridis, Leslie A. Lange, Terho Lehtimäki, Markus M. Lerch,  Allan Linneberg,  Yongmei Liu, Leo-Pekka Lyytikäinen, Ani Manichaikul, Hilary C. Martin,  Koichi Matsuda, Karen L. Mohlke, Nina Mononen,  Yoshinori Murakami, Girish N. Nadkarni, Matthias Nauck, Kjell Nikus, Willem H. Ouwehand, Nathan Pankratz, Oluf Pedersen, Michael Preuss, Bruce M. Psaty, Olli T. Raitakari, David J. Roberts, Stephen S. Rich, Benjamin A.T. Rodriguez, Jonathan D. Rosen, Jerome I. Rotter, Petra Schubert, Cassandra N. Spracklen, Praveen Surendran, Hua Tang, Jean-Claude Tardif, Richard C. Trembath, Mohsen Ghanbari, Uwe Völker, Henry Völzke, Nicholas A. Watkins, Alan B. Zonderman, Peter W.F. Wilson, Yun Li, Adam S. Butterworth, Jean-François Gauchat, Charleston W.K. Chiang, Bingshan Li,  Ruth J.F. Loos, William J. Astle, Evangelos Evangelou, David A. Van Heel, Vijay G. Sankaran, Yukinori Okada, NicoleSoranzo, Andrew D. Johnson, Alexander P. Reiner, Paul L.Auer, Guillaume Lettre

    https://doi.org/10.1016/j.cell.2020.06.045

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