New Paper on Machine Learning-Based Tumor Classification

News, Publications |

A new study published in Nature Genetics, titled “A microenvironment-determined risk continuum refines subtyping in meningioma and reveals determinants of machine learning-based tumor classification,” investigates how tumor microenvironmental features influence risk stratification and computational tumor classification in meningioma. The work shows that meningioma risk is better represented as a continuum shaped by the tumor microenvironment, […]

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Zusammenwirken von natürlicher und künstlicher Intelligenz: Beurteilen-Messen-Bewerten

Publications |

Wie wird das Zusammenleben und -wirken von Menschen und Maschinen zukünftig aussehen? Lassen sich Umfang und Intensität der neuen Synergien bestimmen? Eine wichtige Rolle spielt dabei die Frage, womit wir es beim erweiterten Zusammenwirken mit künstlicher Intelligenz überhaupt zu tun haben. Ansätze, diese begrifflich-theoretisch zu beurteilen, im konkreten Fall messbar zu machen und auch ethisch

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ATF6 activation alters colonic lipid metabolism causing tumor-associated microbial adaptation

Publications |

Endoplasmic reticulum unfolded protein responses (UPRER) contribute to cancer development and the activating transcription factor 6 (ATF6) is involved in microbiota-dependent tumorigenesis. Here, we substantiate the clinical relevance of ATF6 in early-onset and late colorectal cancer patient cohorts. Transcriptional analysis in intestinal epithelial cells (IEC) of ATF6 transgenic mice (nATF6IEC) identified bacteria-specific changes in cellular

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Large language models for surgical informed consent: an ethical perspective on simulated empathy

Publications |

Informed consent in surgical settings requires not only the accurate communication of medical information but also the establishment of trust through empathic engagement. The use of large language models (LLMs) offers a novel opportunity to enhance the informed consent process by combining advanced information retrieval capabilities with simulated emotional responsiveness. However, the ethical implications of

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