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In certain types of cancer, such as leukaemia, high-dose chemotherapy is usually used, which completely or largely destroys the haematopoietic stem cells in the bone marrow. The transfer of healthy donor stem cells then represents the only chance of survival for those affected. However, such an allogeneic haematopoietic stem cell transplant also has side effects […]

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New Recommendations for Optimal Sequencing Depth in Alternative Splicing Studies

As part of an international research team led by Olga Tsoy from the University of Hamburg, the Division of Data Science in Biomedicine contributed to the development of new guidelines for determining the optimal sequencing depth in RNA sequencing (RNA-Seq) studies focusing on alternative splicing (AS). By analyzing extensive RNA-Seq datasets from human tissues such

New Recommendations for Optimal Sequencing Depth in Alternative Splicing Studies Read Post »

New Recommendations for Optimal Sequencing Depth in Alternative Splicing Studies

As part of an international research team led by Olga Tsoy from the University of Hamburg, the Division of Data Science in Biomedicine contributed to the development of new guidelines for determining the optimal sequencing depth in RNA sequencing (RNA-Seq) studies focusing on alternative splicing (AS). By analyzing extensive RNA-Seq datasets from human tissues such

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Epistasis Disease Atlas

The EDA is a comprehensive database focused on epistatic interactions, analyzing how groups of genes work together to cause complex diseases. The atlas currently covers Alzheimer’s, rheumatoid arthritis, bipolar disorder, coronary heart disease, inflammatory bowel disease, type 1 and type 2 diabetes, and hypertension. Data is accessible through a user-friendly R-Shiny app for searching, visualization,

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